The ESR1 gene polymorphisms in patients with coronary artery disease in the southeastern Turkish population

Aim: The objective of this study was to evaluate the prevalence of the estrogen receptor 1 (ESR1) gene variants and their possible association with coronary artery disease (CAD) in Şanlıurfa province. Materials and methods: We used polymerase chain reaction and restriction enzyme digestion to determine the prevalence of the ESR1 gene (NM_001122742.1, GI: 2099): c.454-351 A G (XbaI A G) and c.454-397 T C (PvuII T C) polymorphisms in 100 healthy individuals and 80 angiographically confirmed CAD patients. Results: The body mass index (28.1 ± 5.4), low-density lipoprotein cholesterol (126.1 ± 42 mg/dL), diabetes (n = 13), and hypertension (n = 39) values of the CAD patients were significantly higher than in the control subjects (26.2 ± 3.9, 106.1 ± 26.3, 2, and 18, respectively) (P 0.05). No signifi cant differences were observed in the frequencies of both the c.454-351 A G and c.454-397 T C genotype of the ESR1 gene in CAD patients compared to healthy individuals (P 0.05). Conclusion: Th e ESR1 variants tested in this study were not associated with CAD. Therefore, neither of these 2 variants can be considered as an independent risk factor or a predictor for CAD in the studied Turkish population.