Author/Authors :
GÖRMÜŞ, Uzay Istanbul Bilim University - Faculty of Medicine - Department of Medical Biochemistry, Turkey , TİMİRCİ KAHRAMAN, Özlem Istanbul University - İstanbul Institute for Experimental Medicine - Department of Molecular Medicine, Turkey , TOPTAŞ, Bahar Istanbul University - Istanbul Institute for Experimental Medicine - Department of Molecular Medicine, Turkey , İSBİR, Turgay Yeditepe University - Faculty of Medicine - Department of Medical Biology, Turkey , ÇİFTÇİ, Çavlan Istanbul Bilim University - Faculty of Medicine - Department of Cardiology, Turkey , BERKKAN, Hasan Hakan Istanbul Bilim University - Faculty of Medicine - Department of Medical Biochemistry, Turkey , DALAN, Altay Burak Yeditepe University - Institute of Medical Sciences - Department of Molecular Medicine, Turkey , KARATAY, Mutia Canan Istanbul Bilim University - Faculty of Medicine - Department of Internal Medicine, Turkey
Abstract :
Background/aim: Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels and leptin receptor polymorphisms in a Turkish population. Materials and methods: The sample pool of this study consisted of 202 subjects. G2548A variant in the promoter region of the leptin gene and Q223R polymorphism of the leptin receptor gene were evaluated by using PCR-RFLP. Leptin levels were determined by ELISA. Results: Leptin levels were significantly higher in subjects with the A allele than in subjects without the A allele. Leptin receptor levels were lower in subjects with the AA genotype than in those with the AG genotype. There was a higher prevalence of the leptin-2548 AA genotype among subjects with a BMI ≥ 25 kg/m^2 than in those with a BMI 25 kg/m2.Conclusion: The leptin-2548A allele might be a predisposing factor for obesity.
