Author/Authors :
MACİT, Enis Gülhane Military Medical Academy - Department of Toxicology, Turkey , KIZILGÜN, Murat Dışkapı Children’s Health and Diseases, Hematology, Oncology Training and Research Hospital - Department of Biochemistry, Turkey , ÇAKIR, Erdinç Gülhane Military Medical Academy - Department of Medical Biochemistry, TURKEY , KARAOĞLU, Abdulbaki Gülhane Military Medical Academy - Department of Pediatrics, Turkey , AKGÜL, Emin Özgür Gülhane Military Medical Academy - Department of Medical Biochemistry, TURKEY , ÖZTOSUN, Muzaffer Turkish Armed Forces - Department of Health Services Command, Turkey , AYDIN, İbrahim Gulhane Military Medical Academy - Department of Medical Biochemistry, Turkey , AYDIN, Fevzi Nuri Gulhane Military Medical Academy - Department of Medical Biochemistry, Turkey , AĞILLI, Mehmet Gülhane Military Medical Academy - Department of Medical Biochemistry, Turkey , TÜRKER, Türker Gülhane Military Medical Academy - Department of Public Health, Turkey , OĞUR, Recai Gülhane Military Medical Academy - Department of Public Health, Turkey , GÜLCAN KURT, Yasemin Gülhane Military Medical Academy - Department of Medical Biochemistry, TURKEY , GÜL, Hüsamettin Gülhane Military Medical Academy - Department of Toxicology, Turkey , ÇAYCI, Tuncer Gülhane Military Medical Academy - Department of Medical Biochemistry, Turkey , ÖZKAN, Esin Ankara Occupational Diseases Hospital - Department of Biochemistry, Turkey
Abstract :
Aim: To establish age- and sex-specific reference intervals for essential amino acids in a healthy Turkish pediatric population. Materials and methods: A total of 945 clinically healthy children (531 boys and 414 girls, ranging in age from birth to 14 years) were enrolled. Plasma and urine amino acids’ concentrations were measured by high-performance liquid chromatography. Results: Concentrations of essential amino acids in plasma were higher in girls than in boys in the age groups of 0–1 months and 7–14 years; however, there was no difference in the other age groups. Concentrations of essential amino acids in urine were higher in girls than in boys in the age group of 0–1 months; however, there was no difference in the other age groups. Our results demonstrated the sex-related differences in concentrations of leucine, isoleucine, valine, phenylalanine, lysine, and histidine in plasma, which increased with age in boys but not in girls. The concentrations of leucine, tryptophan, methionine, and lysine in urine declined with age in girls but not in boys, which were sex-related differences, too. Conclusion: We defined essential amino acids’ reference intervals in a Turkish pediatric population.
Keywords :
Reference intervals , plasma , urine , essential amino acids , pediatric
