Author/Authors :
GÜVEN, Mustafa Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Neurosurgery, Turkey , ARAS, Adem Bozkurt Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Neurosurgery, Turkey , TOPALOĞLU, Naci Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Pediatrics, Turkey , ÖZKAN, Adile Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Neurology, Turkey , ŞEN, Halil Murat Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Neurology, Turkey , KALKAN, Yıldıray Recep Tayyip Erdoğan University - Faculty of Medicine - Department of Histology and Embryology, Turkey , OKUYUCU, Ali Ondokuz Mayıs University - Faculty of Medicine - Department of Medical Biochemistry, Turkey , AKBAL, Ayla Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Physical Therapy and Rehabilitation, Turkey , GÖKMEN, Ferhat Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Physical Therapy and Rehabilitation, Turkey , COŞAR, Murat Çanakkale Onsekiz Mart University - Faculty of Medicine - Department of Neurosurgery, Turkey
Abstract :
Background/aim: Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. Materials and methods: The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic acid group sacrificed at 24 h. Obtained brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Results: Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after syringic acid treatment, while increased malondialdehyde levels after ischemia were reduced after treatment. Caspase-3 and caspase-9 values increased after ischemia and decreased after treatment; this reduction was more pronounced at 24 h. Conclusion: Our study revealed that syringic acid treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. In the light of the biochemical and histopathologic results of the present study, we think that syringic acid treatment may be an alternative treatment method.
Keywords :
Brain ischemia , syringic acid , rats , oxidative stress , apoptosis
