Title of article
Antiulcerogenic Activity of Ethanolic Leaf Extract of Croton zambesicus in Rats
Author/Authors
Okokon, Jude E. University of Uyo - Faculty of Pharmacy - Department of Pharmacology and Toxicology, Nigeria , Umoh, Uwem F. University of Uyo - Faculty of Pharmacy - Department of Pharmacognosy and Natural Medicine, Nigeria , Udobang, John A. University of Uyo - Faculty of Pharmacy - Department of Pharmacology and Toxicology, Nigeria , Etim, Emmanuel I University of Uyo - Faculty of Pharmacy - Department of Pharmaceutical and Medicinal Chemistry, Nigeria
From page
119
To page
123
Abstract
Croton zambesicus Muell. Arg. is often used in traditional medicine by Ibibios of Niger Delta region of Nigeria for the treatment of several diseases including gastrointestinal disorders especially ulcer. The antiulcer activity of the ethanolic extract of the crude leaf extract was investigated against indomethacin, ethanol and histamine – induced ulcer models in rats. The crude leaf extract of Croton zambesicus (200 – 600mg/kg) significantly (p 0.001) inhibited chemically – induced ulcers in rats. These effects may in part be due to phytochemical constituents of the extract. The results of this work suggest that the leaf extract of Croton zambesicus possesses antiulcer activity, supporting the ethnomedical use of the plant among the Ibibio tribe of Niger Delta.
Keywords
Croton zambesicus , antiulcer , gastroprotective , stomach , medicinal plant
Journal title
African Journal of Biomedical Research
Journal title
African Journal of Biomedical Research
Record number
2532327
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