Title of article :
Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase Inhibitors
Author/Authors :
Asghariganjeh, Mohammad R. Department of Chemistry - Khuzestan Science and Research Branch - Islamic Azad University , Mohammadi, Ali A. Department of Chemistry - Ahvaz Branch - Islamic Azad University , Tahanpesar, Elham Department of Chemistry - Ahvaz Branch - Islamic Azad University , Rayatzadeh, Ayeh Department of Chemistry - Ahvaz Branch - Islamic Azad University , Makarem, Somayeh Department of Chemistry - Karaj Branch - Islamic Azad University
Abstract :
KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times.
Docking study of some compounds in the active site of α-glucosidase demonstrated that these compounds interacted with important active site residues with low binding energy in comparison to standard inhibitor acarbose.
Keywords :
Alum , Three-component reactions , α-glucosidase , Molecular docking studies , 2-a]pyridine , Tetrahydroimidazo[1
Journal title :
Quarterly Journal of Applied Chemical Research (JACR)
