Title of article :
Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives
Author/Authors :
DOGRUER, Deniz S. Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , ONKOL, Tijen Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , OZKAN, Semiha Gazi Üniversitesi - Faculty of Pharmacy - Department of Microbiology, TURKEY , OZGEN, Selda Gazi Üniversitesi - Faculty of Pharmacy - Department of Microbiology, TURKEY , SAHIN, M. Fethi Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY
Abstract :
Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures ofthese new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. Thesynthesized compounds were evaluated for their antibacterial activity against various gram-positive andgram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 μg/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.
Keywords :
3(2H) , pyridazinone , 1(2H) , phthalazinone , antimicrobial activity
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry
