Title of article :
Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives
Author/Authors :
UNSAL TAN, Oya Hacettepe University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , OZADALI, Keriman Hacettepe University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , YESILYURT, Ozgur Gulhane Military Medical Academy - Psychopharmacology Research Unit, Department of Medical Pharmacology, TURKEY , KAYIR, Hakan Gulhane Military Medical Academy - Psychopharmacology Research Unit, Department of Medical Pharmacology, TURKEY , UZBAY, Tayfun Gulhane Military Medical Academy - Psychopharmacology Research Unit, Department of Medical Pharmacology, TURKEY , BALKAN, Ayla Hacettepe University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY
Abstract :
Some isoxazolo[4,5-d]pyridazin4(5H) -one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
Keywords :
Isoxazolo[4 , 5 , d]pyridazin , 4(5H) , one , hot , plate test , writhing test , analgesic effect
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry
