Synthesis, characterization, and biological activity studies of (E)-N -((thiophen-2-yl)methylene)benzofuran- 2-carbohydrazide and its metal(II) complexes

Metal complexes of the type MLX2 , where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II), and X = Cl and L = TMBC, Schiff base derived from the condensation of benzofuran-2-carbohydrazide with thiophene-2-aldehyde were synthesized. The structure of the complexes was proposed in light of analytical, IR, UV-Vis, 1^H-NMR, FAB-MS, ESR spectral data, and magnetic studies. The complexes were soluble in DMF and DMSO. The measured molar conductance values indicated that the complexes were nonelectrolytic in nature. On the basis of these studies, 6 coordinated octahedral polymeric structures were assigned to the Co(II), Ni(II), and Cu(II) complexes, and 4 coordinated tetrahedral geometries to the Zn(II), Cd (II), and Hg(II) complexes. The Schiff base and its metal complexes were tested for antibacterial and antifungal activities by the MIC method. The DNA cleavage activities of all of the complexes were studied by the agarose gel electrophoresis method.