Title of article :
Synthesis and antimicrobial evaluation of some annelated phthalazine derivatives and acyclo C- nucleosides from 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine precursor
Author/Authors :
EL-HASHASH, Maher Abdel Aziz Ain Shams University - Faculty of Science - Chemistry Department, EGYPT , SOLIMAN, Ahmed Youssef King Khalid University - College of Science - Chemistry Department, SAUDI ARABIA , EL-SHAMY, Ibrahim Essam Fayoum University - Faculty of Science - Chemistry Department, EGYPT
Abstract :
A highly efficient and versatile synthetic approach to the synthesis of annelated phthalazine derivativesviz. 1,2,4-triazolo[3,4-a]phthalazine 11a,b, 14, 18, 19a,b, 29-31, 33, 1,2,4-triazino[3,4-a]phthalazine 25a,b-28, 1,3,5-triazino[4,3-a]phthalazine 22, tetrazolo[5,1-a] phthalazine 23, imidazophthalazine 9a,b,15, and pyrimidinophthlazine 6, 10, 16, 17, 20 is presented. Moreover, acyclo C -nucleoside and double headed acyclo C-nucleoside of 1,2,4-triazolo[3,4-a]phthalazine 12, 13 were obtained via heterocyclization reaction of 1-chloro-4-(2,4,6-trimethylphenyl)phthalazine (4) with gluconic acid hydrazide and galactaric acid bis hydrazide, respectively. The new compounds were synthesized with the objective of studying their antimicrobial activity.
Keywords :
Triazinophthalazine , pyrazolylphthalazine , triazolophthalazine , antimicrobial activity
