Title of article
Preparation of 2-(N,N-dialkylamino)-2,4,6- cycloheptatrien-1-one derivatives from an isocyanide, a primary amine, propionaldehyde, and tropolone via Ugi-Smiles coupling reaction in the presence of silica nanoparticles
Author/Authors
MASSOUDI, Abdolhossain payame noor university - Department of Chemistry, تهران, ايران , AMINI, Issa payame noor university - Department of Chemistry, تهران, ايران , RAMAZANI, Ali islamic azad university - Department of Chemistry, ايران , ZEINALI NASRABADI, Fatemeh zanjan university - Department of Chemistry, زنجان, ايران
From page
779
To page
787
Abstract
The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-(N ,N-dialkylamino)-2,4,6-cycloheptatrien-1-one derivatives. The 4-component reaction of isocyanides, tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines, and propionaldehyde in the presence of silica nanoparticles (silica NPs, ca. 42 nm) proceeds easily in methanol to form the title compounds in a new Ugi–Smiles-type reaction.
Keywords
Ugi , type coupling , tropolone , isocyanides , primary amines , silica (NP) , Ugi–Smiles , type reaction
Journal title
Turkish Journal of Chemistry
Journal title
Turkish Journal of Chemistry
Record number
2533216
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