Bifunctionalized linked bis-spiro[furo[2,3-d]pyrimidine- 6,5 -pyrimidine]2,2 ,4,4 ,6 (3H,3 H,5H)-pentaones derived from one-pot reaction of (thio)barbituric acids with aromatic dialdehydes and BrCN in the presence of Et3N

Reaction of pyrimidine-(1H,3H,5H) -2,4,6-trione (barbituric acid), 1,3-dimethyl pyrimidine-(1H,3H,5H)- 2,4,6-trione (1,3-dimethyl barbituric acid), and 1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H ,5H)-dione (1,3-diethyl thiobarbituric acid) with cyanogen bromide and aromatic dialdehydes in the presence of triethylamine leads to the selective and efficient formation of a novel class of bifunctionalized stable heterocyclic bisspiro[ furo[2,3-d]pyrimidine-6,5 -pyrimidine]2,2 ,4,4 ,6 (3H,3 H,5H)pentaones and their sulfur analogues, which are dimeric forms of barbiturate linked by a phenyl ring. A proposed mechanism was suggested for the formation of the products. The reaction of phthalaldehyde with BrCN and (thio)barbituric acids resulted in only monofunctionalized spiro[furo[2,3-d]pyrimidine-6,5 -pyrimidine]2,2 ,4,4 ,6 (3H,3 H,5H)pentaones, while isophthalaldehyde and terphthalaldehyde resulted in the bifunctionalized form.