Author/Authors :
SVIRIPA, Vitaliy University of Kentucky - College of Medicine,College of Pharmacy,Center for Pharmaceutical Research and Innovation - Department of Molecular and Cellular Biochemistry, USA , CONROY, Michael D. University of Kentucky - College of Medicine - Department of Molecular and Cellular Biochemistry, USA , ZHANG, Wen University of Kentucky - College of Medicine,Lucille Parker Markey Cancer Center - Department of Molecular and Cellular Biochemistry, USA , LIU, Alice University of Kentucky - College of Medicine - Department of Molecular and Cellular Biochemistry, USA , WATT, David S. University of Kentucky - College of Medicine,Center for Pharmaceutical Research and Innovation,Lucille Parker Markey Cancer Center - Department of Molecular and Cellular Biochemistry, USA
Abstract :
Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N -diarylureas were synthesized and evaluated in AMPK-activation studies.
Keywords :
Adenosine monophosphate , activated kinase , biotinylated N , N , diarylureas
