Title of article :
Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold
Author/Authors :
NASUHI PUR, Fazel urmia university - Faculty of Science - Department of Chemistry, اروميه, ايران , NASUHI PUR, Fazel urmia university of medical sciences - Health Technology Incubator Center, ايران , AKBARI DILMAGHANI, Karim urmia university - Faculty of Science - Department of Chemistry, اروميه, ايران
Abstract :
Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.
Keywords :
Calixpenam , Calixarene , 6 , aminopenicillanic acid , nonpenicillinase , Streptococcus strains
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry
