Title of article :
Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies
Author/Authors :
AYHAN EŞİYOK, Peruze Middle East Technical University - Faculty of Arts and Sciences - Department of Chemistry, Turkey , SEVEN, Özlem Middle East Technical University - Faculty of Arts and Sciences - Department of Chemistry, Turkey , EYMUR, Gülüzar Middle East Technical University - Faculty of Arts and Sciences - Department of Chemistry, Turkey , BORA TATAR, Gamze Hacettepe University - Faculty of Medicine - Department of Medical Biology, Turkey , DAYANGAÇ ERDEN, Didem Hacettepe University - Faculty of Medicine - Department of Medical Biology, Turkey , YELEKCİ, Kemal Kadir Has University - Faculty of Engineering and Natural Sciences - Department of Computational Biology and Bioinformatics, Turkey , YURTER, Hayat Hacettepe University - Faculty of Medicine - Department of Medical Biology, Turkey , DEMİR, Ayhan Sıtkı Middle East Technical University - Faculty of Arts and Sciences - Department of Chemistry, Turkey
Abstract :
New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
