Title of article :
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
Author/Authors :
YURTTAŞ, Leyla Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , ÖZKAY, Yusuf Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , DEMİRCİ, Fatih Anadolu University - Faculty of Pharmacy - Department of Pharmacognosy, Turkey , GÖGER, Gamze Anadolu University - Faculty of Pharmacy - Department of Pharmacognosy, Turkey , ULUSOYLAR YILDIRIM, Şafak Anadolu University - Faculty of Pharmacy - Department of Pharmacology, Turkey , ABU MOHSEN, Usama Al-Azhar University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Palestine , ÖZTÜRK, Ömer Anadolu University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , KAPLANCIKLI, Zafer Asım Anadolu University - Graduate School of Health Sciences, Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey
Abstract :
Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a–j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a–j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC 50 values ranging between 30 and 403 µg/mL.
Keywords :
Thiazole , dithiocarbamate , anticandidal activity , cytotoxicity
