Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

1,3-Dipolar cycloaddition of 5-azidomethyl-3- p -substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-( p -substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul- fonyl)-4,5-dihydro-1 H -1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H )-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR ( 1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.