Title of article :
Calixcephems: clustered cephalosporins analogous to calixpenams as novel potential anti-MRSA agents
Author/Authors :
NASUHI PUR, Fazel urmia university - Faculty of Science - Department of Chemistry, اروميه, ايران , NASUHI PUR, Fazel urmia university of medical sciences - Health Technology Incubator Center, ايران , AKBARI DILMAGHANI, Karim urmia university - Faculty of Science - Department of Chemistry, اروميه, ايران
Abstract :
Two novel clusters of cephalosporin based on calixarene were synthesized directly or by ring expansion of the penicillin arms of calixpenams to the corresponding cephem arms via sulfoxide intermediates. Antibiotic tests showed that calixcephems have a noteworthy increase in antibacterial activity against methicillin-resistant strains of Staphylococcus aureus (MRSA) with respect to parent calixpenams and their corresponding single cephems.
Keywords :
Calixcephem , calixpenam , calixarene , cluster , Staphylococcus aureus
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry
