Author/Authors :
YANG, Liangru Henan University of Technology - School of Chemistry and Chemical Engineering, China , BIAN, Huanyu Henan University of Technology - School of Chemistry and Chemical Engineering, China , MAI, Wenpeng Henan University of Technology - School of Chemistry and Chemical Engineering, China , MAO, Pu Henan University of Technology - School of Chemistry and Chemical Engineering, China , XIAO, Yongmei Henan University of Technology - School of Chemistry and Chemical Engineering, China , WEI, Dong Henan University of Technology - School of Chemistry and Chemical Engineering, China , QU, Lingbo Henan University of Technology - School of Chemistry and Chemical Engineering, China
Abstract :
A series of asymmetrical substituted tetrahydropyrimidinium salts and different kinds of bridged bis-tetrahydropyrimidinium salts were prepared through the quaterization of tetrahydropyrimidine or the dehydrogenation of hexahydropyrimidine. They were characterized and used as NHC precursors in the palladium catalyzed Buchwald– Hartwig amination reaction. The in situ formed catalytic system Pd(OAc) 2 /tetrahydropyrimidinium and t BuOK cat- alyzed the amination of heteroaryl halides and heterocyclic amines effectively, producing the heterocyclic amine functionalized heteroaryl derivatives in high yields.
Keywords :
Tetrahydropyrimidinium salt , Buchwald–Hartwig amination , microwave irradiation , palladium catalysis , N , heterocyclic carbene
