Author/Authors :
BABAEI, Hossein tabriz university of medical sciences - Faculty of Pharmacy - Drug Applied Research Center, تبريز, ايران , SADEGHPOUR, Omid iran university of medical sciences - Research Institute for Islamic and Complementary Medicine, تهران, ايران , NAHAR, Lutfun University of Ulster - School of Biomedical Sciences, UK , DELAZAR, Abbas tabriz university of medical sciences - Faculty of Pharmacy - Drug Applied Research Center, تبريز, ايران , NAZEMIYEH, Hossein tabriz university of medical sciences - Faculty of Pharmacy - Drug Applied Research Center, تبريز, ايران , MANSOURI, Mohammad Reza islamic azad university - Faculty of Agriculture, ايران , POURSAEID, Naser islamic azad university - Faculty of Agriculture, ايران , ASNAASHARI, Solmaz tabriz university of medical sciences - Faculty of Pharmacy - Drug Applied Research Center, تبريز, ايران , Bamdad MOGHADAM, Sedigheh tabriz university of medical sciences - Faculty of Pharmacy - Drug Applied Research Center, تبريز, ايران , Dey SARKER, Satyajit University of Ulster - School of Biomedical Sciences, UK
Abstract :
Amygdalus lycioides var. horrida (Spach) Browicz (Rosaceae), also known as Prunus lycioides (Spach.) Schneid., is an endemic Iranian species of the genus Amygdalus. In Iranian traditional medicine, the aerial parts and roots of A. lycioides are used in the treatment of diabetes. Six flavonoids, i.e. quercetin 3-O-rhamnoside (1), luteolin 7-O-rhamnoside (2), isorhamnetin 3-O-rutinoside (3), kaempferol 3-O-rhamnoside (4), apigenin (5), and naringenin (6), have been isolated from the aerial parts of this plant. The structures of these compounds were elucidated by UV, MS, and NMR spectroscopic data analyses. While the antioxidant activity of these compounds was assessed by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the vasorelaxant effect was determined using the rat aortic vascular smooth muscle. Compounds 1-6 displayed significant antioxidant activity, with the RC50 values ranging from 0.0033 to 0.5186 mg/ml. Compound 2 showed a considerable vasorelaxant activity on rat aortic vascular smooth muscle in a dose-dependent manner.
Keywords :
Amygdalus lycioides var. horrida , Rosaceae , flavonoid , antioxidant , DPPH , vasorelaxant
