Author/Authors :
JAVMEN, Artur JSC “Biocentras”, Lithuania , JAVMEN, Artur State Scientific Research Institute Centre for Innovative Medicine - Department of Immunology, Lithuania , NEMEIKAITĖ-ČĖNIENĖ, Aušra State Scientific Research Institute Centre for Innovative Medicine - Department of Immunology, Lithuania , GRIGIŠKIS, Saulius JSC “Biocentras”, Lithuania , JONAUSKIENĖ, Irena State Scientific Research Institute Centre for Innovative Medicine - Department of Immunology,, Lithuania , RUDENKOV, Mark JSC “Biocentras”, Lithuania , KAČIANAUSKAS, Darius JSC “Biocentras”, Lithuania , MAURICAS, Mykolas State Scientific Research Institute Centre for Innovative Medicine - Department of Immunology, Lithuania
Abstract :
β-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of β-glucan. Saccharomyces cerevisiae, baker’s yeast, is one of the commonly used sources of β-1,3-glucan. The aim of this work was to investigate S. cerevisiae β-glucan immunomodulatory activity against cancer cells. In our experiments, BALB/c mice were fed with insoluble whole β-glucan particles, and then their blood was collected for experiments. MH- 22a hepatoma cells were treated with the blood of mice fed with β-glucan, and tumor cell viability was investigated after the treatment. The obtained results demonstrated that leukocytes in vivo primed with whole glucan particles, in combination with soluble β-glucan, decreased MH-22a hepatoma cell viability in vitro. Our study has indicated that β-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.
Keywords :
β , Glucan , yeast , cancer , mice
