Title of article :
A Comparative Evaluation of the Flow and Compaction Characteristics of α-Cellulose obtained from Waste Paper
Author/Authors :
Ohwoavworhua, FO National Institute for Pharmaceutical Research and Development (NIPRD) - Department of Pharmaceutical Technology and Raw Materials Development, Nigeria , Adelakun, TA National Institute for Pharmaceutical Research and Development (NIPRD) - Department of Pharmaceutical Technology and Raw Materials Development, Nigeria , Kunle, OO National Institute for Pharmaceutical Research and Development (NIPRD) - Department of Pharmaceutical Technology and Raw Materials Development, Nigeria
Abstract :
Purpose: Alpha-cellulose obtained as pulp from fibrous plant materials has found use in the pharmaceutical industry as a disintegrant and direct compression diluent. The aim of thisstudy was to evaluate the suitability of α-cellulose obtained from waste paper as a direct compression excipient. Method: The flow and compaction characteristics of α-cellulose (ACP) obtained from waste paper, in comparison with Avicel PH 101, using the Kawakita and Heckel models were evaluated. Result: The results indicate that the flow properties of these materials could not be predicted accurately using the Kawakita model. A comparison of compression behaviour andcompactibility of the two powders showed Avicel PH 101 to be a slightly better binder. Conclusion: It was concluded that ACP material could find use as a potential dry binder and direct compression diluent in tableting as the binding properties were comparable to those of Avicel PH 101.
Keywords :
Alpha , cellulose , microcrystalline cellulose , flow and compaction characteristics , direct compression diluent.
Journal title :
Tropical Journal of Pharmaceutical Research
Journal title :
Tropical Journal of Pharmaceutical Research
