Title of article :
Formulation of Fast-Dissolving Tablets of Promethazine Theoclate
Author/Authors :
Sharma, Shailesh Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy - Department of Pharmaceutics, Pharmaceutics Research Division, Dosage Form Design Laboratory, India , Sharma, Neelam Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy - Department of Pharmaceutics, Pharmaceutics Research Division, Dosage Form Design Laboratory, India , Gupta, Ghanshyam Das Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy - Department of Pharmaceutics, Pharmaceutics Research Division, Dosage Form Design Laboratory, India
Abstract :
Purpose: To optimize and formulate promethazine theoclate fast-dissolving tablets that offer a suitable approach to the treatment of nausea and vomiting. Method: The solubility of promethazine theoclate was increased by formulating it as a fast-dissolving tablet containing β-cyclodextrin, crospovidone, and camphor, using direct compression method. A 3^3 full factorial design was used to investigate the combined influence of three independent variables - amounts of camphor, crospovidone and β-cyclodextrin - on disintegration time, friability and drug release after 5 min.Result: The optimization study, involving multiple regression analysis, revealed that optimum mountsof camphor, crospovidone and β-cyclodextrin gave a rapidly disintegrating/dissolving tablet. A checkpoint batch was also prepared to verify the validity of the evolved mathematical model. The optimized tablet should be prepared with an optimum amount of β-cyclodextrin (3.0 mg), camphor (3.29 mg) and crospovidone (2.61 mg) which disintegrated in 30 s, with a friability of 0.60 % and drug release of 89 % in 5 min. Conclusion: The optimized approach aided both the formulation of fast-dissolving theoclate tablets and the understanding of the effect of formulation processing variables on the development of the formulation.
Keywords :
Fast , dissolving tablet , 3^3 Factorial design , Promethazine theoclate , Optmization studies.
Journal title :
Tropical Journal of Pharmaceutical Research
Journal title :
Tropical Journal of Pharmaceutical Research