Title of article :
Chemical Composition and Cytotoxic Activities of Petroleum Ether Fruit Extract of Fruits of Brucea javanica (Simarubaceae)
Author/Authors :
Su, Zhiwei Chinese Academy of Sciences - South China Botanical Garden - Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Program for Natural Product Medicinal Chemistry and Drug Discovery, China , Su, Zhiwei University of Chinese Academy of Sciences, China , Huang, Huijuan South China Normal University - Guangdong provincial Key Lab of Biotechnology for Plant Development, China , Li, Jinlian Chinese Academy of Sciences - South China Botanical Garden, Foshan Biotech and Pharmaceutical Center - Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Program for Natural Product Medicinal Chemistry and Drug Discovery, China , Zhu, Yuehui Chinese Academy of Sciences - South China Botanical Garden - Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Program for Natural Product Medicinal Chemistry and Drug Discovery, China , Huang, Riming Chinese Academy of Sciences - South China Botanical Garden - Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Program for Natural Product Medicinal Chemistry and Drug Discovery, China , Qiu, Samuel X. Chinese Academy of Sciences - South China Botanical Garden - Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Program for Natural Product Medicinal Chemistry and Drug Discovery, China
Abstract :
Purpose: To investigate the chemical composition and antitumor activity of the petroleum ether extract of the dried ripe fruits of Brucea javanica. Methods: The composition of petroleum ether extract was analyzed by gas chromatography/mass spectrometric (GC/MS) and their antitumor activities were determined by MTT assay. Results: GC/MS spectrometry results indicate that the petroleum ether extract was a mixture of esters, fatty acids, sterides, pregnanones, terpenes, alkaloids, alkenes, alcohols, ketones, aldehydes and other compounds. The results also revealed the significant antitumor activity of the extract with IC50 of 9.14, 12.45, 15.15, 16.13, 22.26, and 27.97 μg/mL against A549, CNE, MCF-7, NCI-H460, HepG2, and KB-3-1 cell lines, respectively. Conclusion: The study establishes the chemical composition and cytotoxic activity of the petroleum ether extract of the plant fruits. There is need for further investigations to isolate more potent compounds and structurally modify the known compounds to retain activity and lower toxicity and thus lead to the possible development of Brucea javanica oil.
Keywords :
Brucae javanica , Mass spectra , Cytotoxic activity , Anti , tumour.
Journal title :
Tropical Journal of Pharmaceutical Research
Journal title :
Tropical Journal of Pharmaceutical Research
