Novel three-component synthesis of functionalized pyrrolidone: study antioxidant and antimicrobial activity

An efficient synthesis of functionalized pyrrolidone is described. This involves the three-component reaction of benzoyl isothiocyanates and secondary amines in the presence of activated acetylenes. We investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Furthermore, the disk diffusion test on Gram positive and negative bacteria are utilized for investigation of antimicrobial activity of some pyrrolidones. The achieved outcomes of this experiment demonstrate that these synthesized compounds could prevent from growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this process.