Title of article :
Determination of trimester specific reference intervals for thyroid hormones during pregnancy in Malaysian women
Author/Authors :
THEVARAJAH, M university of malaya - Faculty of Medicine - Department of Pathology, Malaysia , CHEW, YY university of malaya - Faculty of Medicine - Division of Laboratory Medicine, Malaysia , LIM, SC university of malaya - Faculty of Medicine - Department of Endocrinology, Malaysia , SABIR, N university of malaya - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , SICKAN, J
Abstract :
Objective: To establish trimester specific reference intervals for thyroid hormones during pregnancy in Malaysian women. Study design: Cross-sectional observational study performed in the Obstetric Clinic, University Malaya Medical Centre. A single blood sample from 626 women at various trimesters of pregnancy was analyzed for thyroid function. TSH, FT4, TT4, FT3 and TT3 values at each trimester of pregnancy were calculated. Results: From the TSH, FT4, TT4, FT3 and TT3 results, reference values based on mean +2SD was calculated for the hormones at each trimester of pregnancy. Conclusion: We calculated clinically relevant trimester-specific reference values for thyroid function tests through pregnancy to facilitate improved management of thyroid disease in pregnancy in our local population.
Keywords :
trimester , specific , reference values , pregnancy , thyroid function
Journal title :
The Malaysian Journal of Pathology
Journal title :
The Malaysian Journal of Pathology
