The value of lipoprotein (A) and homocysteine estimation in patients with deep venous thrombosis of the lower limb

This work was undertaken to evaluate the levels of the serum lipoprotein (a) and total homocysteine as a risk factors in patients with deep venous thrombosis of lower limb 40 patients (28 females and 12 males) with deep venous thrombosis of the lower limb, twenty matched apparently healthy subjects (11 males and 9 females) were chosen as a control group, we classified patients into a groups, I II group according to sex, III IV according to site of thrombus V VI group according to recurrence of episodes the following investigations were done: CBC, prothrombin time and concentration, activated partial thromboplastin time, fasting serum glucose, kidney function tests, liver function tests and lipogram, measurements of lipoprotein (a) and assay of homocysteine as a special investigations. There was a significant increase serum lipoprotein (a) and total plasma homocysteine concentrations in patients with deep venous thrombosis and there was also a positive correlation between serum lipoprotein (a) and total plasma homocysteine levels in patients with deep venous thrombosis, homocysteine levels were affected by sex difference while lipoprotein (a) levels showed no sex difference, lipoprotein (a) and homocysteine levels show no difference in patients with deep venous thrombosis whether first diagnosed or recurrent, homocysteine levels were positively correlated with age in patients with deep venous thrombosis. We therefore suggest that serum lipoprotein (a) and total plasma homocysteine concentrations acts as a major and important risk factor for the precipitation of venous thromboembolic events.