Treatment of Unruptured Ectopic Pregnancy with Single-Dose of Methotrexate

Objective: The purpose of this study was to determine success rate with single-dose intramuscular methotrexate therapy for the treatment ectopic pregnancy. Study Design: This was a retrospective review of patient who were treated with methotrxate from may 2003 to april 2006. Successful treatment was defined as resolution of ectopic pregnancy without surgical intervention. Setting: Tertiary centre. Result: Our overall sucss rate was 90% (90/100 patient). The median pre treatment serum P-human chorionic gonadotropin level was lower in those women in whom treatment was successful compared with those women with treatment failure (3158 Vs 9249mIU/ml, p 0.000l). The median time till resolution of ectopic was 30.7 days. A positive correlation was found between pre treatment p hCG level and time to resolution (r=0.844). Eight patients with positive ectopic cardiac activity were treated with an 75% success rate. Conclusion: This large series indicates that single-dose methotrexate for treatment of ectopic pregnancy is associated with an excellent rate.