EFFECT OF INHALATION BOLUS DOSE SEVOFLURANE VERSUS INTRAVENOUS BOLUS DOSE PROPOFOL ON CARDIAC PARAMETERS DURING ATTENUATION OF HEMODYNAMIC STRESS RESPONSE : A DOPPLER STUDY

Both sevoflurane and propofol were used to control surgical hemodynamic responses. This study was conducted to compare the effect of inhalation bolus dose sevoflurane and bolus dose propofol on cardiac parameters using esophageal Doppler (CardioQ-ODM). Method: Sixty patients scheduled for elective herniorrhaphy were randomized into two groups: Group S (n=30) and Group P (n=30). When positive sympathetic response occurred (defined as15% increase in heart rate (HR) and mean arterial pressure (MAP)), patients in Group S received inhalation bolus of sevoflurane 8 vol% in 6 LPM O2 while patients in Group P received bolus propofol 300mcg/kg/min. Both boluses were maintained until return of MAP and HR to baseline measurements. Esophageal doppler was inserted immediately after intubation. Cardiac parameters: cardiac output, cardiac index, stroke volume, stroke volume index, peak velocity and flow time corrected were recorded 10 minutes after intubation (T0) which were considered baseline values, with occurrence of sympathetic response (T1) and with return of MAP and HR to baseline values (T2). Results: There was significant reduction (P 0.05) in cardiac parameters in Group P compared to Group S. Conclusion: The present study concluded that inhalation bolus dose sevoflurane attenuated hemodynamic responses similar to propofol with less myocardial depressant effects and in shorter time.