Title of article
Phenytoin-induced acute liver injury case report: possible drug interactions and risk factors
Author/Authors
Aboul-Fotouh, Sawsan Ain Shams University - Faculty of Medicine - Department of Pharmacology, Clinical Pharmacology Unit, Egypt , Abdallah, Nihad Ain Shams University - Faculty of Medicine - Department of Anesthesia and Intensive Care, Egypt , Aboul-Ez, Sally Ain Shams University - Faculty of Medicine - Department of Pharmacology, Clinical Pharmacology Unit, Egypt , El-Shaer, Ahmed Ain Shams University - Faculty of Medicine - Department of Anesthesia and Intensive Care, Egypt , Abdel-tawab, Ahmed M. Ain Shams University - Faculty of Medicine - Department of Pharmacology, Clinical Pharmacology Unit, Egypt
From page
329
To page
331
Abstract
Phenytoin is a widely used anticonvulsant drug in the ICU that requires therapeutic drug monitoring. It carries a major risk of dose-related toxicity because of its saturation (zero-order) pharmacokinetic. Hepatic injury with phenytoin is common and varies from almost trivial to massive necrosis and is usually hepatocellular. Here, we report on a 45-year-old woman who was admitted to the ICU with subarachnoid hemorrhage and developed an acute liver injury 16 days after phenytoin injection. Phenytoin was stopped and replaced by oxcarbazepine. Possible drug interactions and risk factorsare also discussed.
Keywords
ICU , liver injury , phenytoin
Journal title
Ain Shams Journal of Anesthesiology(ASJA)
Journal title
Ain Shams Journal of Anesthesiology(ASJA)
Record number
2538688
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