Title of article :
A Study of Autoimmunity in Children with Thalassemia Major
Author/Authors :
TAMAN, KHALED H. Ain Shams University - Institute of Postgraduate Childhood Studies - Department of Pediatrics, Egypt , SALAMA, KHALED M. Cairo University - Faculty of Medicine - Department of Pediatrics, Egypt , AHMAD, ABDEL FATTAH M. Atomic Energy Authority - Department of Biochemistry, Egypt , EL ADHAM, EITHAR K. Atomic Energy Authority - Department of Pediatrics, Egypt , BAYOUMI, MOHAMAD M. Atomic Energy Authority - Department of Physiology, Egypt
Abstract :
Aim: This study was subjected to estimate the most common autoimmune complications in thalassemics and the prevalence of different auto antibodies so as to evaluate its correlation with personal data including age, sex, growth parameters, hepatitis C antibody status, ferritin level and type of iron chelation therapy. Methodology: Different Abs including anticardiolipin, antihistone, ANA, antierythropoietin by ELISA technique, hepatitis C virus by ELISA and. Ferritin by IRMA (Immune radiometric assay), result of the study were analyzed by appropriate statistical methods. Results: ANA were positive in 13.3%, antierythropoietin antibodies were positive in 15% of cases while antierythro-poietin antibodies were positive in 93.3% of cases and they were not significantly related to HCV antibody status or type of chelation. The mean age of hepatitis C virus negative cases was significantly lower than hepatitis C virus positive cases, ferritin levels were significantly higher in patients on deferipone than those on desferioxamine. Conclusion: The presence of auto antibodies especially antierythropoietin antibodies is prevalent among thalassemia major patients.
Keywords :
Autoimmunity – Thalassemia
Journal title :
The Medical Journal of Cairo University
Journal title :
The Medical Journal of Cairo University
