Author/Authors :
rezk, ahmad benha university - faculty of medicine - department of obstetrics gynecology, egypt , edris, amal benha university - faculty of medicine - department of clinical pathology, Egypt , ouda, mossad m. benha university - faculty of medicine - department of clinical pathology, Egypt , fathy, naglaa benha university - faculty of medicine - department of clinical pathology, Egypt , mohamad, shaimaa benha university - faculty of medicine - department of clinical pathology, Egypt
Abstract :
Objective: The aim of this study is to clarify the value of the aetiological diagnosis of mutation in thrombophilic genes gene, prothrombin gene and methylenetetrahydrofolate reductase gene in women with repeated IVF-embryo transfer failure with unknown causes. Methods: Women with two or more previously failed IVF-embryo transfer cycles with unknown causes were included. The control was divided into 2 groups; group A included women who conceived spontaneously with no previous history of miscarriage and group B included women who have had successful pregnancy after their first IVFembryo transfer cycle. Results: There are high statistically significant increases in the number of patients either heterozygous or homozygous with factor V, prothrombin and methylenetetrahydrofolate reductase genes mutation in the study group. Conclusion: These data suggest that factor V, prothrombin and methylenetetrahydrofolate reductase gene mutation may have a significant role in repeated implantation failure following IVF/ICSI treatment cycles
