Patterns of hepatitis B infection in Egyptian children in the era of obligatory hepatitis B vaccination

Background and aims: Mass compulsory HBV vaccination was applied in Egypt in 1992. The first dose of vaccine is administered at 2 months of age and routine screening of pregnant women for HBsAg is not applied. We aimed to evaluate the pattern of HBV infections after the implementation of HBV vaccination in Egyptian children. Methods; Fifty-six children with HBV infection presented to the Pediatric Hepatology Unit, Cairo University Children s Hospital over the period from 1992-2006. Their data were reviewed for risk factors, clinical, serological and histopaihological profiles. These cases were followed up for 6.3±3.4 years. The data of those born before 1993 (did not receive HBV vaccine) (Group I) was compared to those who received the vaccine (Group II). Results: Sixty percent of HBV infected cases were born before 1993. Comparison of data of both groups revealed: 1-A significant younger age of onset in group II (3.34±3.31 years vs. 9.84±2.95 years; /?= 0.01). 2- Vertical transmission was a significant risk factor in group II. 3- Chronic hepatitis developed in almost half of cases in both groups but cirrhosis was diagnosed only in 4 cases (all from group I) (p=0.04). Conclusions: Vertically transmitted HBV infection is becoming an important risk factor for acquisition of HBV among children born after the era of mass vaccination in Egypt. Mass screening for HBsAg of pregnant Egyptian women and/or giving a birth, dose of HBV vaccine is becoming mandatory with the increased incidence of vertical transmission.