Title of article :
Mycoplasma-pneumoniae-Induced Thrombotic Thrombocytopenic Purpura
Author/Authors :
SHOENFELD، Y. نويسنده , , Meir، E. Bar نويسنده , , Amital، H. نويسنده , , Levy، Y. نويسنده , , Kneller، A. نويسنده , , Bar-Dayan، Y. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
-111
From page :
112
To page :
0
Abstract :
Thrombotic thrombocytopenic purpura (TTP) is a fatal disease characterized by widespread platelet aggregation, hemolytic anemia and fever with renal and neurological involvement. Different factors have been associated with the development of TTP, e.g. infections, pregnancy, chemotherapy, drug therapy and bone marrow transplantation. Recent data imply that all these different causes may induce the disease by decreasing the activity of the plasma von Willebrand factor-cleaving protease resulting in unusually large von Willbrand factor multimers that later on initiate the cascade of TTP. In this communication, we present a unique association between infection with Mycoplasma pneumoniae and TTP. We believe that the emergence of antibodies that cross-react with Mycoplasma and the protease might elucidate in this case the pathogenesis of TTP.
Journal title :
Acta Haematologica
Serial Year :
2000
Journal title :
Acta Haematologica
Record number :
25399
Link To Document :
بازگشت