DuraSeal Xact Adhesion Barrier and Sealant System: An Advanced Hydrogel Technology for Watertight Dural Repair in Spinal Cases

Introduction: Cerebrospinal fluid leakage is a major problem in neurosurgical operations. A large variety of biologic and artificial materials have been suggested as sealant for achieving a watertight dural closure. We prospectively evaluated the safety and efficacy of a duraSeal Xact adhesion barrier and sealant system in patients with predicted CSF leaks after sutured spinal dural closure. Material and Methods: This study is a prospective clinical trial in 25 patients who need spinal dural augmentations. DuraSeal Xact system was used in 19 patients underwent intentional spinal durotomy and 6 patients who had unintended incidental durotomy. Patients were followed up for 3 months postoperatively with clinical examinations and diagnostic imaging. Results: DuraSeal Xact system was effective in preventing CSF leaks in all patients. We have observed only 2 complications with uncertain relationship with the used system. Conclusion: DuraSeal Xact system meets the clinical challenge to reliably seal the dura to prevent CSF leak. It may also facilitate subsequent reoperations by acting as a mechanical barrier to adhesion formation.