Immunohistochemical Evaluation of EGFR and HER-2/NEU Expression in Renal Cell Carcinomas and Their Prognostic Significance

Renal cell carcinoma (RCC) represents about 1% to 3% of all visceral cancers and accounts for 85% of renal cancers in adults. Literatures related to incidence and epidemiology of renal cell carcinoma have confirmed its increasing incidence. The purpose of this study is to evaluate expression of EGFR and HER-2/NEU in cases of renal cell carcinoma and to correlate their expression with pathological prognostic factors. This study consisted of 40 cases of renal cell carcinoma. In the current study 18 cases showed immunoreactivity for EGFR (45% of total cases) while 25 cases showed immunoreactivity for HER-2/NEU (63% of total cases). Statistical analysis for a possible correlation between EGFR and HER-2/NEU expression and the various prognostic factors in this study (tumor stage, nuclear grade, macrocapsular invasion, microcapsular invasion, macrovascular invasion and microvascular invasion) had revealed non significant correlation.