Effect of Platelet Rich Plasma on Healing of Distracted Mandibular Segment

Introduction: Recent efforts to improve wound healing have focused on auto genus sources of bioactive mediators , such as platelet rich plasma (PRP), which offer the potential to enhance the bone healing, the aim of this work was to study the effect of platelet rich plasma on distraction osteogenesis. Patients and Methods: Ten patients (7 females and 3 males), their ages ranged from 7 years to 23 years (with a mean of 14.45 years). They presented with bilateral mandibular hypoplasia. All patients were treated with bilateral mandibular distraction osteogenesis, using intra and extra-oral unidirectional distractors, platelet rich plasma was applied only at left site while the right site act as a control. The follow-up periods were 3 months, 6 month and one year using panoramic X-ray which was analyzed by special soft wares to determine the amounts of formed bone and its gray level also axial computerized tomography was used to measure bone density in Hounse field units. Results: The gray level at the right site was 101/256± 6.50 and that of left site was 108.7±7.30 with no significant difference p .05.: The amount of formed bone at the right site was 294185 pexils±1.018, while that of the left site was 366921.5 pexils±1.70 with no significant difference p .05 between the right and left sites. The CT density at the right site was 537.9 HU±35.32 and that of left site was 501HU±53.37 with no significant difference p .05. Conclusion: The platelet rich plasma has no significant role in distraction osteogenesis as regard amount of formed bone and its density.