Eradication of Helicobacter Pylori Infection in Patients with Morbid Obesity and its Effect on the Components of Metabolic Syndrome

Introduction: Many studies were done in the past few years to assess any relation between helicobacter pylori infection and metabolic syndrome- related morbidity including cardiovascular disease but most of these studies had reported conflicting results. Aim of the Work: To evaluate the changes in the components of metabolic syndrome and inflammatory parameters after helicobacter pylori eradication in patients with morbid obesity. Subjects and Methods: We conducted a prospective, openlabel, longitudinal, single-center study included 136 consecutive patients suffering from morbid obesity fulfilling the criteria of metabolic syndrome and had helicobacter pylori infection betweenl January 2010, and 30 December 2012. Patients were referred to the Gastroenterology Unit of Farwaniya Hospital (regional hospital in Kuwait) for endoscopic evaluation of the possibility of sleeve gastrectomy surgery. All patients received the current standard triple therapy for 2 weeks. The metabolic and inflammatory parameters were assessed before and 6 weeks after eradication. Results: Helicobacter pylori eradication rates were 68.75% with per protocol analysis and 64.7% with intention-to-treat analysis. Among the 88 patients with successful eradication, there were no significant differences in all variables before and after eradication of helicobacter pylori infection. There is minor increase in the mean of weight after eradication of helicobacter pylori but with no significant difference. Conclusion: Helicobacter pylori eradication has no effect on metabolic and inflammatory parameters including lipid profile, blood sugar, insulin resistance and C-reactive protein in patients with morbid obesity.