Serum Resistin as a Predictor of Outcome in Traumatic Head-Injured Patients in Intensive Care Unit of Suez Canal University Hospital

Objective: To assess serum resistin levels as a predictor of outcome in ICU patients with traumatic head injuries at Suez Canal University Hospital, to improve outcomes in such patients. Patients and Methods: In total, 48 patients with severe traumatic brain injury (TBI) were included. Plasma samples were obtained on admission and at days 3 and 5 after TBI. Resistin concentrations were measured using an enzymelinked immunosorbent assay (ELISA). Outcome (morbidity and mortality) was assessed at 14 days in the ICU using the Glasgow Outcome Scale (GOS). Results: The mean age of the patients was 32.3±8.1 years; most were males (91.7%). The mean GOS on admission was 6/15. Most of the patients showed multiple findings on CT (58.3%). Twelve (25%) patients died. A multiple logistic regression model showed that GOS on admission 7/15, random blood sugar (RBS) on admission 200mg/dL, and bilateral non-reactive pupils in the assessment were significant predictors of 14-day mortality (ORs: 1.3, 1.9, and 1.69, respectively) and a resistin level on admission to the ICU of 0.618ng/mL was also a significant predictor of 14-day mortality (sensitivity of 100%, specificity of 77.8%, PPV of 60%, and a NPV of 100%). Conclusions: Resistin may be useful as a novel biomarker in TBI as an adjuvant prognostic tool to predict poor outcome.