Pattern of Serum Inhibin B Hormone Secretion in Polycystic Ovarian Disease

Background: Inhibin selectively inhibits FSH but not LH secretion. Data are somewhat conflicting regarding differences in inhibin between normally cycling women and those with polycystic ovarian syndrome (PCOS). The Aim of this Study: Is to study the pattern of inhibin-B hormone secretion in cases of PCOS throughout days 3, 5 and 9 of their menstrual cycles. Patients and Methods: The study was performed on 29 women with PCOS, 5ml of blood were collected at days 3, 5 and 9 of the menstrual cycle of each participant for Measurement of inhibin-B hormone. Results: Inhibin B hormone showed an increase in con-centration along the studied days of menstrual cycle. There was a highly significant negative correlation between day 3 as well as day 5 inhibin B concentrations and body mass index (BMI), while day 9 inhibin B concentrations showed a non significant correlation with BMI. Day 3, 5 and 9 inhibin B concentrations showed a non significant correlation with age as shown in Table (3). Conclusion: Inhibin B can’t be used alone to diagnose a case of PCOS due to absence of a characteristic pattern of secretion.