Medicinal Attributes of Rumex Vesicarius (Polygonaceae) Growing in Sakaka, Al-Jouf, Saudi Arabia

Objective: The present research aimed to study the antioxidant, antiproliferative and anti-microbial effects of aqueous extracts of Rumex vesicarius (AERV) leaf, flower and leaf plus flower. Material and Methods: Extracted samples in vitro assays i.e total phenolic content, total flavonoids, antioxidant capacity and cytotoxic activity were evaluated against MCF-7, NCI-H460 and SF-268 human cancer cell lines, in comparison with normal WI 38, Also the antibacterial activity of AERV was determined. Results: The results show that the aqueous extract (AE) has total phenolic and total flavonoid contents. The high potential of antioxidant activity and its antitumor activity is a dose-response manner. Flower extract of rumex treatment was found to be the most as effective antioxidant and antiproliferative. The evaluation of antimicrobial activity of AERV, demonstrated that ethanolic flower extract, showed higher antimicrobial activity than water extract and Salmonella Typhimurium was the most sensitive isolates as compared with other sensitive and resistant isolates. Minimum inhibitory concentration of the ethanolic flower extract was 235mg/ml. Conclusion: The study revealed a considerable antioxidant, antiproliferative and anti-microbial potential in two parts of Rumex vesicarius. The obtained data in this work might be used for further study of extracts of Rumex vesicarius in various applications such as health supplementation and pharmaceutical benefits.