Effects of Propofol on Ischaemia-Induced Ventricular Arrythmias in Rats

The effects of anesthetics on ischemia-induced ventricular arrhythmias are still poorly studied. The Aim of the Study: Is to investigate the effects of propofol on ischaemia-induced ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic effect of propofol during acute myocardial ischemia. Under anesthesia with intraperitoneal sodium pentobarbital male albino rats were divided into 4 groups (each 10 rats); The first group was the control group, second group was sham operated group, the third group was propofol-treated group (given propofol 39mg/Kg/hr), and the fourth group was propofol (39mg/Kg/hr), and atropine (1mg/kg) treated group. Results: In propofol-treated group marked reduction of ventricular arrhythmia was observed; in propofol atropinetreated group moderate reduction of ventricular arrhythmia was observed. Conclusion: Propofol has beneficial effects on ischemia-induced arrhythmias via modulation of the autonomic nervous system and/or a principal gap-junction protein, connexin 43 (Cx43).