Hemodynamics and Respiratory Stability during Awake Craniotomy: Dexmedetomidine-Based Sedation Versus Propofol-Based Sedation

Background: Awake craniotomy aims to remove most of the brain tumour while preserving the eloquent area of the brain, many factors affecting hemodynamics and respiration during awake craniotomy especially sedative drugs: Type and doses. Aim: To detect hemodynamics and respiratory effects of dexmedetomidine-based sedation and propofol-based sedation in patients undergoing awake craniotomy for resection of brain tumours, which has encroachment on eloquent area of the brain. Patients and Methods: Randomized, prospective, comparative clinical trial study was carried out on 28 patients of both sexes undergoing elective surgery for brain tumor resection in the routine surgical lists in Suez Canal University Hospital, from January 2012 to April 2014, patients are divided into two equal groups (14 patients): Propofol group and dexmedetomidine group. Results: There were more hemodynamically stability and respiratory stability among dexmedetomidine group, there were statistically significant difference between the two groups in some time intervals. Conclusions: Dexmedetomidine provide more hemodynamically stability and less effects on respiration during awake craniotomy.