Primary Extra Nodal Non-Hodgkin s Lymphomas

Background and Aim: Non Hodgkin Lymphoma (NHL) is the second most common cancer in adults in Egypt, primary extra nodal lymphoma PENL represent 25-40% of NHL. The study aims to assess histopathological and epidemiological aspects PENL.Material and Methods: Forty-six patients of histological proved pENL treated during the period (2008-2013) in Assuit University Hospital Oncology Department, data were collected and analyzed. Results: Median age the patients was 50 years, 30% had B-symptoms and 33% had elevated LDH. Gastrointestinal Lymphomas (GIL) was the most common site in 37% of pENL, followed by head and neck lymphomas, skin, bone and CNS in 30, 20, 9, 4% respectively. PENL had B immunophenotype in 85% whereas only 15% of patients had T cell immunophenotype. Diffuse Large B-Cell Lymphoma, (DLBCL) was the most common histological type observed in 48%, followed by marginal zone lymphoma of MALT in 22%. Stage I, II, III was 9, 56, 35% respectively, 76% of patients received chemotherapy with CHOP regimen. Response to treatment was evaluated in 41 patients, the main response was complete remission in 56%, followed by 44% was partial response.Conclusion: PGIL was the most common pENL followed by H N. DLBCL is the most common pathology followed by MALT and the high response in absence of Rituximab may be due to early stages in our study (65%), low and low intermediate IPI in 88% of patients.