Author/Authors :
El-Kosasy, Amira, M. Ain Shams university - bPharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams university, Abbassia, Cairo, Egypt, Egypt , El-Aziz, Omar, Abd Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams, university, Abbassia, Cairo, Egypt, Egypt , Ebrahim, Naglaa Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams,university, Abbassia, Cairo, Egypt, Egypt , Fattah, Laila, Abdel Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Misr university for science and technology,6thOctober, Giza, Egypt, Egypt
Abstract :
Two novel Torasemide (TOR) sensors were investigated, using B-cyclodextrin and calix[4]arene as ionophores, where linear responses within concentration ranges of (10-7-10-2 and 10-8-10-2M) and Nernstian slopes of (58.77 and 59.214 mV/decade) over the pH range of 7-12 were obtained, respectively.The selectivity coefficients of the developed sensors indicate excellent selectivity for TOR, where the second sensor shows a higher sensitivity if compared to the first one. The proposed fabricated sensors display useful analytical characteristics for the determination of TOR (for anti-doping purpose) in bulk powder, biological fluids and in pharmaceutical formulation.
Keywords :
Torasemide , B , cyclodextrin , Calix[4]arene , Potentiometry , Antidoping , Plasma , Urine ,
