Author/Authors :
SHAKER, OLFAT G. Cairo University - Faculty of Medicine - Department of Medical Biochemistry and Molecular Biology, Egypt , EL-SHEHABY, AMAL R. Cairo University - Faculty of Medicine - Department of Medical Biochemistry and Molecular Biology, Egypt , ZAHRA, AMR A. Fayoum University - Faculty of Medicine - Department of Medical Biochemistry and Molecular Biology, Egypt , ABD EL-ALEEM, OMAYMA O. Fayoum University - Faculty of Medicine - Department of Medical Biochemistry and Molecular Biology, Egypt , YOUSRY, AYMAN Cairo University - Faculty of Medicine - Department of Tropical Medicine, Egypt
Abstract :
Background: Hepatocellular Carcinoma (HCC) is the most common type of liver cancer. Liver transplantation is a lifesaving and effective treatment of end-stage liver failure. However transplant recipients can suffer from serious side effects of long-term immunosuppression and they can lose their allografts because of rejection.Aim of the Work: Our aim is to evaluate the value of serum miR-122, miR-194 and miR-148a as predictors of rejection of liver transplantation.Subjects and Methods: Blood samples were taken from 30 HCC patients who prepared to liver transplantation process. Also 50 blood samples from controls were taken. Serum was separated for detection of: MiR-122, miR-194 and miR-148a by real time RT-PCR.Results: There was significant difference between rejected and non-rejected patients as regards the mean values of miR-122 and miR-148a [(p=0.001) and (p=0.027) respectively].Conclusion: MiR-122 and miR-148a can be used as predictors of rejection of liver transplantation.
