Is Glycemic Control Predicting One Year Change in Low Density Lipoprotein Levels in Young Adult with Type 1 Diabetes Mellitus?

Objective: To test if the change in glycated hemoglobin (HbA1c) over a follow-up interval of approximately one year would be associated with concomitant changes in Low Density Lipoprotein Levels Cholesterol (LDL.C) in young adult with Type 1 Diabetes (T1D). Also to determine T1DM patients who would be eligible for lipid-lowering medications based on American Diabetes Association (ADA) guidelines. Methods: Our prospective cohort study included 81 patients with T1D who attended and follow in Diabetes out patient s clinics of Kuwait primary health care centersduring the period of 2013-2014; for them, recordeddatafor age, sex, duration of diabetes, Body Mass Index (BMI), HbA1c and LDL. C at the beginning and at the end of one year duration were included in this study. Results: We are reporting data on a population of n=81 subjects with T1DM with mean age (19.38±6.332 years). Female and male distribution was 48.1 % and 51.9 respectively, Means of HbAlc and LDL.C at initial visit were (10.8±2% and 2.9±0.9mmol/l) and (9.8±2% and 2.6±0.8mmol/l) after one year of follow-up. Our result showedthat there was significant positive correlation between HbAlc and LDL.C at beginning (r=0.312; p=0.005) and (r=0.259; p=0.019) afterone year of follow-up; which means that change in HbAlc over time was significantly associated with change in LDL.C. Conclusions: As LDL.C considered a major risk factor for coronary heart disease in patients with diabetes, so our study revealed that improved glucose control was associated with a more favorable LDL.C levelsand this reflect that in the case of adolescents with type 1 diabetes, good control of diabetes seems to be of paramount importance.