Impact of Resisted Exercise Training on C-Reactive Protein and Interleukin-10 in Type II Diabetic Patients with Depression

Background and Purpose: Resisted exercise is an efficacious treatment for diabetic patients with depression, diabetic patients with depression have elevated inflammatory cytokines but unknown either exercise affects inflammation or non, so the effect of three months resisted exercise training on C-reactive protein and Interleukin-10 in Diabetic patients with depression were studied. Patients and Methodology: Forty men Diabetic patients with depression with age of 30-50 years were included in the present study. Their body mass index was ranged from 25 to 29.9kg/m² (overweight). They were randomly divided into two groups; each group consisted of twenty patients. Group (A) The study group received a program of resisted exercise (40-50min, resisted exercises, 3 times/week) with low calorie diet (1200cal/d) and Group (B) The control group that received only low-calorie diet, both groups were under their medical treatment prescribed by the Psychologist and physician. The biochemical changes in CRP and IL-10 were measured at the beginning of the study and after twelve weeks. The Results: Showed that a program of resisted exercise with low calorie diet had greater effect to significantly decrease C-reactive protein by (–18.1%) and significantly increase Interleukin-10 by (19.1%), while the control group showed non statistical significant changes. Conclusion: A program of resisted exercise training with low calorie diet showed statistically significant reduction in CRP and statistically significant increase in IL-10 which considered as important inflammatory markers in progression of chronic diseases.