The Usefulness of Intraoperative Measurement of Beta Natriuretic Peptide in Evaluating Diastolic Dysfunction in Patients Undergoing on-Pump Coronary Artery Bypass Grafting

Background: Diastolic dysfunction pathogenesis gave rise to an increase in Left Ventricular Filling Pressure (LVFP) due to decreased Left Ventricular (LV) compliance; this is reflected on an increase in serum B-type Natriuretic Peptide (BNP) levels. In the current study we aimed to assess the association between serum BNP level and the occurrence of diastolic dysfunction and its usefulness to predict postoperative complications in patients candidate for Coronary Artery Bypass Graft (CABG) surgery. Methods: We prospectively enrolled 40 patients candidate for on pump CABG surgery. The following echocardiographic parameter: Early diastolic mitral annular velocity (e ) was recorded and BNP samples were withdrawn both at the fol-lowing time interval; before skin incision, after sternal closure and 24 hours postoperatively. Postoperative complications defined as Major Cardiac Events (MCE), Acute Kidney Injury (AKI) and need for mechanical Ventilation more than 48 hours (Vent 48) were recorded. Results: Serum BNP levels showed a strong association with diastolic dysfunction (p 0.05) as well as with the occur-rence of postoperative MCE and AKI (p 0.05). Conclusion: Good correlation exists between E/e ratio and BNP level. Both of them showed good association with diastolic dysfunction and with the occurrence of postoperative complications.