Does Dexmedetomidine Affects dosing of Inotropic Support at the End of Pediatric Cardiac Surgeries?

Background: During repair of a congenital heart defects the child s heart is exposed to myocardial hypoxia. Impaired myocardial function after cardiopulmonary bypass (CPB) and surgical repair in children remain a commonly encountered clinical problem.Alpha-2 agonists decrease central noradrenergic activity of the locus coeruleus with a decrease in systemic adrenaline and noradrenaline production.Methods: The present study included 40 pediatric patients undergoing repair of congenital heart defects with CPB including cyanotic and acyanotic patients, with average age of 6 months-8 years.Patients were randomly allocated into 2 equal groups: • Group (A): Dexmedetomidine group (n=20).• Group (A): Dexmedetomidine group (n=20).Objective: To detect if dexmedetomidine affects dosing of inotropic support at the end of pediatric cardiac surgeries.Conclusion: The studied dose of Dexmedetomidine, which provided myocardial protection as messured by biochemical markers of myocardial injury, didn t affect dosing of inotropic support at the end of pediatric cardiac surgeries.